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MS Trial Atlas
McDonald criteria evolution
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The pivotal Phase III trials that shaped modern multiple sclerosis treatment.
Landmark publication
Order
Chronological
Alphabetical
Study
Therapy
Today
1985
1990
1995
2000
2005
2010
2015
2020
2025
2030
REMODEL-1 & 2
Remibrutinib
→
FENhance 1 & 2
Fenebrutinib
→
FENtrepid
Fenebrutinib
→
HERCULES
Tolebrutinib
→
PERSEUS
Tolebrutinib
→
GEMINI 1 & 2
Tolebrutinib
→
OPTIMUM
Ponesimod
→
SUNBEAM
Ozanimod
→
EXPAND
Siponimod
→
OPERA I & II
Ocrelizumab
→
ORATORIO
Ocrelizumab
→
TOWER
Teriflunomide
→
TOPIC
Teriflunomide
→
CARE-MS I
Alemtuzumab
→
CONFIRM
Dimethyl fumarate
→
DEFINE
Dimethyl fumarate
→
FREEDOMS II
Fingolimod
→
TRANSFORMS
Fingolimod
→
FREEDOMS
Fingolimod
→
CLARITY
Cladribine
→
TEMSO
Teriflunomide
→
CAMMS223
Alemtuzumab
→
AFFIRM
Natalizumab
→
PRISMS
Subcutaneous interferon beta-1a
→
MIMS
Mitoxantrone
→
Copolymer 1 pivotal trial
Glatiramer acetate
→
MSCRG
Intramuscular interferon beta-1a
→
IFNβ-1b subcutaneous pivotal trial
Interferon beta-1b
→
Today
Timeline range 1985 through 2030.